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Sorbitol is a sugar alcohol used as a humectant and sweetener in toothpaste. It is generally recognized as safe for oral use, but excessive ingestion can lead to gastrointestinal discomfort.

Standard mild toothpaste abrasive — safe at typical use.

Standard formulation ingredient — neither beneficial nor harmful at typical use.

Sodium fluoride is commonly used in toothpaste for its cavity-fighting properties. However, it is considered a neurotoxin at high doses and has been linked to various health concerns, making its safety controversial, especially for children who may ingest toothpaste.

Sodium saccharin is an artificial sweetener that has been linked to health concerns, including potential carcinogenic effects. Its use in toothpaste raises safety concerns, particularly for children who may ingest it.